# required libraries
library("PKPDmisc")
library("ggplot2")
library("dplyr")
##
## Attaching package: 'dplyr'
##
## The following objects are masked from 'package:stats':
##
## filter, lag
##
## The following objects are masked from 'package:base':
##
## intersect, setdiff, setequal, union
library("mlxR")
library("reshape2")
library("knitr")
knitr::opts_chunk$set(echo=FALSE)
ORAL FORMULATION
1. PK profile of 100 mg oral (SD)
(PK profile of 100 mg oral, SD (t=0), CL = 0.1 L/hr, V = 1 L, ka = 0.5/hr, F = 0.8)
1a. Patient’s clearance decreases by 25%.
(PK profile of 100 mg oral, SD (t=0), CL = 0.075 L/hr, V= 1 L, ka = 0.5/hr, F=0.8)
1b. Patient’s clearance decreases by 50%.
(PK profile of 100 mg oral, SD (t=0), CL = 0.05 L/hr, V= 1 L)
1c. Overlay plot of patient with decreased clearance and normal clearance.
(PK profile of 100 mg oral, SD (t=0), CL = 0.1, 0.075, 0.05 L/hr, V=1, Ka = 0.8)
2. Patient is administered 100 mg oral loading dose and a 100 mg maintenance dose every 6 hours.
(PK profile of 100 mg oral, LD (t=0), MD (q= 6 hr), CL = 0.1 L/hr, V = 1 L, ka = 0.5/hr, F = 0.8)
2a. Patient’s clearance decreases by 25%.
(PK profile of 100 mg oral, LD (t=0), MD (q= 6 hr), CL = 0.075 L/hr, V= 1 L, ka = 0.5/hr, F=0.8)
2b. Patient’s clearance decreases by 50%.
(PK profile of 100 mg oral, LD (t=0), MD (q= 6 hr), CL = 0.05 L/hr, V= 1 L, ka = 0.5/hr, F=0.8)
2c. Patient consumes a high fat meal 48 hours after beginning treatment, which reduces bioavailability by 50%.
(PK profile of 100 mg oral, LD (t=0), MD (q=6 hr), CL = 0.1 L/hr, V = 1 L, ka = 0.5/hr, F=0.8, 0.4)
2d. Overlay plot of patient with decreased clearance and normal clearance.
(PK profile of 100 mg oral, LD (t=0), MD (q=6 hr), CL = 0.1, 0.075, 0.05 L/hr, V = 1 L, ka = 0.5/hr, F=0.8)
2e. Overlay plot of patient with normal bioavailability and decreased bioavailability.
(PK profile of 100 mg oral, LD (t=0), MD (q=6 hr), CL = 0.1 L/hr, V = 1 L, ka = 0.5/hr, F=0.8, 0.4)
3. Patient is administered 100 mg oral loading dose, followed by a maintenance dose of 100 mg every 12 hours.
(PK profile of 100 mg oral, LD (t=0), MD (q=12 hr), CL=0.1 L/hr, V=1L, ka=0.5/hr, F=0.8)
3a. Patient’s clearance decreases by 25%.
(PK profile of 100 mg oral, LD (t=0), MD (q= 12 hr), CL = 0.075 L/hr, V= 1 L, ka = 0.5/hr, F=0.8)
3b. Patient’s clearance decreases by 50%.
(PK profile of 100 mg oral, LD (t=0), MD (q=12 hr), CL = 0.05 L/hr, V= 1 L, ka=0.5/hr, F=0.8)
3c. Patient consumes a high fat meal 48 hours after beginning treatment, which reduces bioavailability by 50%.
(PK profile of 100 mg oral, LD (t=0), MD (q=12 hr), CL = 0.1 L/hr, V = 1 L, ka = 0.5/hr, F=0.4)
3d. Overlay plot of patient with decreased clearances and normal clearance.
(PK profile of 100 mg oral, LD (t=0), MD (q=12 hr), CL = 0.1, 0.075, 0.05 L/hr, V = 1 L, ka = 0.5/hr, F=0.8)
3e. Overlay plot of patient with normal bioavailability and decreased bioavailability.
(PK profile of 100 mg oral, LD (t=0), MD (q=12 hr), CL = 0.1 L/hr, V = 1 L, ka = 0.5/hr, F=0.8, 0.4)
4. Patient is administered a 100 mg loading dose, followed by a maintenance dose of 100 mg every 24 hours.
(PK profile of 100 mg oral, LD (t=0), MD (q=24 hr), CL = 0.1 L/hr, V=1L, ka=0.5/hr, F=0.8)
4a. Patient’s clearance decreases by 25%.
(PK profile of 100 mg oral, LD (t=0), MD (q= 24 hr), CL = 0.075 L/hr, V= 1 L, ka = 0.5/hr, F=0.8)
4b. Patient’s clearance decreases by 50%.
(PK profile of 100 mg oral, LD (t=0), MD (q= 24 hr), CL = 0.05 L/hr, V= 1 L, ka=0.5/hr, F=0.8)
4c. Patient consumes a high fat meal 48 hours after beginning treatment, which reduces bioavailability by 50%.
(PK profile of 100 mg oral, LD (t=0), MD (q=24 hr), CL = 0.1 L/hr, V = 1 L, ka = 0.5/hr, F=0.4)
4d. Overlay plot of patient with decreased clearances and normal clearance.
(PK profile of 100 mg oral, LD (t=0), MD (q=24 hr), CL = 0.1, 0.075, 0.05 L/hr, V = 1 L, ka = 0.5/hr, F=0.8)
4e. Overlay plot of patient with normal bioavailability and decreased bioavailability.
(PK profile of 100 mg oral, LD (t=0), MD (q=6 hr), CL = 0.1 L/hr, V = 1 L, ka = 0.5/hr, F=0.8, 0.4)
5. Overlay plots of all dosing intervals
## Session info --------------------------------------------------------------
## setting value
## version R version 3.2.2 (2015-08-14)
## system x86_64, darwin13.4.0
## ui X11
## language (EN)
## collate en_US.UTF-8
## tz America/New_York
## date 2015-12-09
## Packages ------------------------------------------------------------------
## package * version date source
## assertthat 0.1 2013-12-06 CRAN (R 3.2.0)
## colorspace 1.2-6 2015-03-11 CRAN (R 3.2.0)
## DBI 0.3.1 2014-09-24 CRAN (R 3.2.0)
## devtools 1.9.1 2015-09-11 CRAN (R 3.2.0)
## digest 0.6.8 2014-12-31 CRAN (R 3.2.0)
## dplyr * 0.4.3 2015-09-01 CRAN (R 3.2.0)
## evaluate 0.8 2015-09-18 CRAN (R 3.2.0)
## formatR 1.2.1 2015-09-18 CRAN (R 3.2.0)
## ggplot2 * 1.0.1 2015-03-17 CRAN (R 3.2.0)
## gtable 0.1.2 2012-12-05 CRAN (R 3.2.0)
## htmltools 0.2.6 2014-09-08 CRAN (R 3.2.0)
## knitr * 1.11 2015-08-14 CRAN (R 3.2.2)
## labeling 0.3 2014-08-23 CRAN (R 3.2.0)
## lazyeval 0.1.10 2015-01-02 CRAN (R 3.2.0)
## magrittr 1.5 2014-11-22 CRAN (R 3.2.0)
## MASS 7.3-44 2015-08-30 CRAN (R 3.2.0)
## memoise 0.2.1 2014-04-22 CRAN (R 3.2.0)
## mlxR * 2.2.0 2015-05-31 CRAN (R 3.2.0)
## munsell 0.4.2 2013-07-11 CRAN (R 3.2.0)
## PKPDmisc * 0.3.4.3 2015-10-17 Github (dpastoor/PKPDmisc@2d99b00)
## plyr 1.8.3 2015-06-12 CRAN (R 3.2.0)
## proto 0.3-10 2012-12-22 CRAN (R 3.2.0)
## R6 2.1.1 2015-08-19 CRAN (R 3.2.0)
## Rcpp 0.12.1 2015-09-10 CRAN (R 3.2.0)
## reshape2 * 1.4.1 2014-12-06 CRAN (R 3.2.0)
## rmarkdown 0.8.1 2015-10-10 CRAN (R 3.2.2)
## scales 0.3.0 2015-08-25 CRAN (R 3.2.0)
## stringi 0.5-5 2015-06-29 CRAN (R 3.2.0)
## stringr 1.0.0 2015-04-30 CRAN (R 3.2.0)
## XML 3.98-1.3 2015-06-30 CRAN (R 3.2.0)
## yaml 2.1.13 2014-06-12 CRAN (R 3.2.0)